Rarely 1998-2013 Street Glide or Ultra CVO models have factory MTX branded speakers and amplifiers. Some have no factory amplifiers. If your CVO Street Glide or Ultra has no factory amp or has the MTX branded amplifiers then this radio will be plug n play and retain the factory amplifiers. More common we see CVO Street Glide or Ultra models with a Harman Branded amplifier mounted under the Tour Pak of Limited models. These amplifiers can not be retained and must be replaced and rewired. All of these have a Harman branded radio which is not what we are looking for. You need to check the amplifier brand. This also applies to non CVO models that have added on  a Harmon amplifier.